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Stage de Master 2 en Biology (COLON-MICROBIOME) H/F
ASNR
Source: Headcount Labs · original listing ↗
Job data: Headcount Labs, ODbL 1.0. Job descriptions belong to their employers.
Source date: 11/4/2026
About this role
Type de contrat : Convention de stage Description du poste : This Master Thesis internship will be performed in the Experimental Radiotoxicology and Radiobiology Laboratory (LRTOX) headed by Dmitry Klokov. The successful candidate will be supervised by Guillaume Varès and will work with a postdoc. They will use an inducible CRC mouse model, establish mouse intestinal organoids to study how LDR can potentiate CRC initiation and progression, and perform experiments to characterize and modulate the gut microbiota in this model. Thématique : The evaluation of cancer risk associated with exposure to low doses of ionizing radiation (LDR) is a major challenge. In this project, the candidate will use an inducible colon cancer mouse model (KPC:APC) and histological analysis to understand how LDR may induce changes in the tumor microenvironment, leading to colon cancer progression. Additional cellular and molecular characterizations will be performed in intestinal organoids. The candidate will perform metagenomics sequencing to characterize the role of gut microbiota in this model. Applicants should have experience in a related area/subject: cancer research, biomedical sciences, cell and molecular biology, radiobiology and/or toxicology. Candidates with previous laboratory experience (particularly in cell and molecular biology) and/or familiarity with murine models, organoids, intestinal biology or microbiology are particularly encouraged to apply. - Working methods: Structured and results oriented. - Personality: Self-motivated and team-oriented. - Languages: Proficiency in English or French. e de données de radiotoxicologie expérimentale.